In 2006, she crossed over to the mainstream of Latin pop after her collaboration with Mexican singer Julieta Venegas in the radio hit "Eres para mí".

Tijoux is the daughter of Chilean parents living in political exile in France during Augusto Pinochet's dictatorship in Chile.

This album put Makiza at the top of the Latin American hip-hop market, as their style was much more evolved than other groups at the time.

In 2004, Makiza came back together and announced a tour to promote the re-release of Vida Salvaje, which was remastered and in CD format.

Tijoux and Seo2, the only musically active remaining members of the group, decided to reunite the band and work on new material.

In January 2007, Tijoux collaborated again with Julieta Venegas on her song "Eres para mi" from her album Limón y sal.

In September 2007, Tijoux released her first solo album under the independent label Oveja Negra, founded by the Sociedad Chilena del Derecho.

On 29 June 2009, Tijoux performed at the Mexican music festival Vive Latino and continued touring across Mexico soon thereafter.

The album was largely autobiographical, exploring themes from her own life that included the death of a close friend, experiencing creative crises, friendships, and bad luck, among others.

[6] In September 2012, Tijoux was featured in a campaign called "30 Songs / 30 Days" to support Half the Sky: Turning Oppression into Opportunity for Women Worldwide, a multi-platform media project inspired by Nicholas Kristof and Sheryl WuDunn's book.

[11] In November 2020, Tijoux was included on the BBC's 100 Women 2020 list, highlighting her involvement "in campaigns against inequality and oppression in the world".

She returned to Chile with her parents aged 14, and was given a scholarship to study at a private school for French immigrants located in Vitacura.

[18][19] She has expressed support for the environment, especially the protection of indigenous cultural practices related to nature such as in "Río Abajo" from Vengo.

"Shock" from her 2011 album La Bala became an anthem of a student protest movement in the early 2010s that addressed the unaffordable costs of higher education in the country.

[24] Protesters are said to have appreciated the song's anti-capitalist messaging and its condemnation of "shock doctrine," a political strategy used by Augusto Pinochet's dictatorship where hurtful economic policies are installed in the wake of chaotic events and reinforced with violence.

[26] In 2019, Tijoux posted a video montage of protests happening in Chile with her newly released song “Cacerolazo” playing in the background, whose lyrics reflect the policies that culminated in the action and broader historical context for the movement such as aftereffects of Pinochet's rule.

[28] MC Millaray’s involvement adds a Mapuche voice, an indigenous group in part located in Chile.