[1] She was the daughter of emperor Alexios III Angelos and Euphrosyne Doukaina Kamatera.
Soon after Anna's father became emperor, in 1195, Isaac Komnenos was dispatched to combat the Uprising of Asen and Peter.
He was captured, became a pawn between rival Bulgarian and Vlach factions, and died while imprisoned.
[6][7] Her second marriage to Theodore Laskaris, future emperor of Nicaea, was celebrated in a double wedding in late 1199/early 1200 (the other couple was Anna's sister Irene and Alexios Palaiologos).
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