She was the mother of Emmanuel Armand de Vignerot du Plessis, Duke of Aiguillon (1720-1788), future General and Secretary of State for Foreign Affairs.
She held a literary salon in her hotel on Rue de l'Université, Paris, welcoming philosophers, economists and Encyclopédistes.
Mindful of her own interests, the Duchesse d'Aiguillon kept a watchful eye on her estates, making frequent visits to Aiguillon in Guyenne.
[4] Shortly before his death, Montesquieu entrusted the Duchesse d'Aiguillon with the corrected manuscript of Lettres Persanes, telling her: "Consult with my friends, and judge whether this should appear".
[2] After her husband's death in 1750, she became dowager duchess and lost interest in the duchy, which reverted to her son, Emmanuel Armand.