Anne Williams-Isom (born November 17, 1964) is an American government official, academic, lawyer and former nonprofit executive who has been serving as New York City deputy mayor for Health and Human Services since January 2022.

[4][5][6] Williams-Isom holds the James R. Dumpson chair of child welfare studies at Fordham Graduate School of Social Service.

In 1996, Williams-Isom joined the New York City Administration for Children's Services as the director of the Office of Community Planning and Development.

[7] In 2006, under during the Mayoralty of Michael Bloomberg, she was promoted to deputy commissioner of community and government affairs at the New York City Administration for Children's Services.

[10][11] In December 2021, Mayor-elect Eric Adams named Williams-Isom as the incoming deputy mayor for Health and Human Services.