Antelope is a census-designated place (CDP) in Todd County, South Dakota, United States.

As of the census[3] of 2000, there were 867 people, 225 households, and 177 families residing in the CDP.

There were 233 housing units at an average density of 102.0 per square mile (39.4/km2).

The racial makeup of the CDP was 2.19% White, 96.89% Native American, and 0.92% from two or more races.

16.9% of all households were made up of individuals, and 8.9% had someone living alone who was 65 years of age or older.