He played college football for the Purdue Boilermakers and was selected by the Cowboys in the first round of the 2007 NFL draft with the 26th overall pick.

By the time Spencer was through, he ended his high school career by setting team records in tackles and sacks.

A diverse athlete, Anthony lettered in both football and basketball, and this helped him get accepted to Purdue University.

He was named the Indianapolis Star's Defensive Lineman of the Year as a senior, when his team went undefeated and won the 2002 Class 2A state championship.

He also batted down six passes and forced three fumbles, earning All-Big Ten Conference honorable mention.

[8] Spencer was converted to an outside linebacker and named the starter opposite to DeMarcus Ware, while Greg Ellis was recovering from his Achilles surgery.

Despite the overall disappointment of Dallas's season, Spencer put in a solid 16 starts, recording 63 tackles, 5 sacks, and 2 forced fumbles.

[9] Spencer also recorded 6 sacks, 1 pass deflection and 4 forced fumbles in 15 starts as the Dallas Cowboys finished the season 8-8 with no playoff appearance.

More than a month later, and just before the 2012 NFL draft, He officially signed the franchise tag, guaranteeing him a salary of $8.856 million for the 2012 season.

[10] Spencer ended up having a break out season and being named to his first Pro Bowl as an injury replacement for Green Bay's Clay Matthews.

[12] After remaining a free agent for over a month, Spencer re-signed with the Cowboys with a one-year deal on April 26.

His recovery ramped up at the end of training camp and was able to come back for the fourth game against the New Orleans Saints.

He was solid against the run and steadily improved as a pass rusher, finishing with 17 quarterback pressures (tied for fourth on the team).

On April 10, 2015, Spencer signed a one-year contract with the New Orleans Saints as a free agent.