He played in 10 games (2 starts), collecting 40 tackles (9 for loss), 5 sacks, 12 quarterback pressures, 2 passes defensed and one forced fumble.
He also made the Dean's List and received the Jim Tatum award for the ACC's top student athlete, because of his academic achievements.
In 2001, he was named the starter at right defensive end, but suffered a herniated disc in the season-opener against the Tampa Bay Buccaneers and had surgery on September 17.
He returned to practice on a limited basis on November 9, but still suffered pain and was forced to be placed on the injured reserve list on December 21.
He was eventually deactivated in the thirteenth game against the Philadelphia Eagles, with Eric Ogbogu taking his starting position in that contest and against the Washington Redskins.
On March 10, 2004, he signed with the Cleveland Browns as a free agent, reuniting with defensive coordinator Dave Campo, who was his head coach with the Cowboys.
On March 30, Ekuban along with defensive tackle Michael Myers, were traded to the Denver Broncos in exchange for running back Reuben Droughns.
Ekuban missed the entire 2007 season due to a right Achilles tendon tear, suffered in the second preseason game against his former team, the Dallas Cowboys.
[7] In 2008, he was re-signed to a one-year $3.12 million contract, to compete with Jarvis Moss and John Engelberger for the left defensive end position.
He finished the season with 49 tackles, 5 sacks (tied for the team lead), one pass defensed and one fumble recovery in 15 games (10 starts).