He played college football for the Wisconsin Badgers and was selected 31st overall by the Cowboys in the first round of the 2013 NFL draft.

Frederick is now the co-founder & chief operating officer of the tabletop role-playing game company Demiplane.

In order to preserve a year of Frederick's NCAA eligibility, Wisconsin coaching staff decided to redshirt him in 2010.

[4] In his redshirt sophomore season, Frederick replaced John Moffitt, starting 11 of 13 games at left guard.

[5] Considered the best center in his class by Mel Kiper Jr. of ESPN, Frederick decided to enter the 2013 NFL draft as an underclassman.

[12] This decision caused a stir in the media because it was not only seen as a reach, but the trade was also criticized for bringing poor compensation after moving down 13 positions.

He became the first rookie in franchise history to start every game at center and was selected to the NFL All-Rookie team.

[14][15] The next year, he continued his development, by anchoring what was arguably considered as the best offensive line in the league and was also named to his first Pro Bowl.

In 2015, he had to work with four different starting quarterbacks with varying degrees of knowledge of the team's offense, which required him to make more protection calls.

[16] On August 13, 2016, Frederick signed a six-year, $56.4 million contract extension with the Cowboys, making him the highest-paid center in the league.