He played college football for the UConn Huskies, and was selected by the Dallas Cowboys in the first round of the 2015 NFL draft after a stellar combine performance.

A free agent after his fifth season, Jones signed a five-year, $82 million contract with the Miami Dolphins, making him the highest-paid cornerback in the NFL at the time.

The next year, he was switched to cornerback, starting 11-of-12 games, while registering 60 tackles (fourth on the team), 3 interceptions and 8 passes defensed.

[5] He missed the rest of the season after undergoing surgery for a shoulder injury suffered in a loss against East Carolina University.

On March 31, 2015, Jones attended UConn's pro day, along with Deshon Foxx, Geremy Davis, B. J. McBryde, and five others.

[12] Jones had private workouts and visits with the Buffalo Bills, Philadelphia Eagles, Chicago Bears, and San Francisco 49ers.

[21] Throughout training camp, Jones competed for a job as a starting cornerback, against Morris Claiborne and Tyler Patmon, after Orlando Scandrick tore his MCL and ACL.

[22] Head coach Jason Garrett named Jones the backup cornerback behind Brandon Carr and Morris Claiborne.

Jones finished the 2016 season with 88 combined tackles (73 solo), ten pass deflections, and an interception in 16 games and 16 starts.

On January 15, 2017, Jones started his first career playoff game and recorded five solo tackles and deflected two passes in a 34–31 loss at the Green Bay Packers in the NFC Divisional round.

On October 29, 2017, he made five combined tackles, broke up a pass, and returned an interception by Kirk Cousins for a 21-yard touchdown in a 33–19 victory at the Washington Redskins.

[38] On March 21, 2020, Jones signed a five-year, $82 million contract with the Dolphins, making him at the time the highest-paid cornerback in the NFL.

In Week 14 against the Kansas City Chiefs, Jones forced a fumble on Mecole Hardman that was recovered by the Dolphins and intercepted a pass thrown by Patrick Mahomes during the 33–27 loss.

[40] In Week 17 against the Buffalo Bills, Jones recorded his career high second interception of the season off a pass thrown by Josh Allen during the 56–26 loss.

On July 21, 2022, Jones was placed on the reserve/PUP list at the start of training camp, but ultimately missed the entire season while recovering from a left Achilles surgery performed in March.

[42] On February 25, 2023, he wrote on Twitter: "Today I can't run or jump because of my injuries sustained playing this game.

[43][44] On March 15, 2023, the Dolphins designated Jones for release after he failed a physical exam, citing salary cap reasons.