Antilla is a municipality in Holguín Province of Cuba.

It was founded in January 21, 1925 as a railroad terminal and port town.

It is located on the north-eastern shore of Cuba, on a peninsula between the Gulf of Nipe and Banes Bay.

The municipality covers 101 km2 (39 sq mi) and contains the communities of Bijarú, Canalito, Cortaderas, Deleite, Este Cabecera, Los Novillos, Oeste Cabecera, San Jerónimo and Sao de los Hidalgos.

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