Antiochus served as an officer under Philip II, and gained distinction as a military general.
Antiochus married a Macedonian woman called Laodice and in about 358 BC Laodice gave birth to their son Seleucus I Nicator, who became a general of Alexander the Great and later founded and became the first king of the Seleucid Empire; she also gave birth to their daughter, Didymeia.
It was pretended, in consequence of a dream which Laodice had, that the god Apollo was the real father of Seleucus.
When Seleucus became king, he founded and named 16 cities in honor of his father, including the Syrian city of Antioch (now situated in modern Turkey) and the Seleucid Military Outpost, Antioch, Pisidia.
Through Seleucus, Antiochus had thirteen Seleucid kings bearing his name, as well as various monarchs from the Kingdom of Commagene.