[2] A New Orleans institution, it is notable for being the birthplace of several famous dishes, such as Oysters Rockefeller,[3] pompano en papillote, Eggs Sardou and Pigeonneaux Paradis.

During this time, Jules also acquired property around the original restaurant as it became available, including a former slave quarters and carriage house.

The restaurant has a non-seasonal à-la-carte menu that features dishes with regional influences such as turtle, pompano, redfish, and shellfish, with preparation techniques that reflect a French aesthetic.

Antoine's is also known for Café Brûlot, a drink made from coffee, orange liqueur, cinnamon stick, sugar, cloves, and lemon peels.

[2] Antoine's requires all aspiring servers to spend two to three years in its apprentice program before they "make waiter".

[2] In the 1951 Bugs Bunny cartoon French Rarebit, a reference to Antoine's plays a pivotal role, as Bugs convinces two Parisian chefs to let him show them how to cook "Louisiana Back-Bay Bayou Bunny Bordelaise", exclusively because it is "a la Antoine".

[8] Antoine's itself is not pivotal to the plot, which hinges on the murder of a woman from a snobbish-but-impoverished old Creole family, just as she was beginning to face a serious chronic illness.

Rather, Antoine's is part of the ambience of New Orleans, which Keyes depicts as an exotic, half-foreign city whose ways are not easily understood by outsiders, especially those from the North.

Antoine's is mentioned in other novels by Keyes, including Once on Esplanade, Crescent Carnival, The River Road, and its sequel, Vail D'Alvery.

In the second, which lasts several minutes, Jim Garrison (played by Kevin Costner) has lunch with his staff in the Large Annex Room.

At the beginning of the segment, he is greeted by the real maitre d'hôtel, Henri Alciatore, a direct descendant of the founder.

Two years after Katrina, the restaurant nearly declared bankruptcy due to zero customer base but managed to hold on.