In 2004 Vidokle co-organized e-flux video rental with Julieta Aranda, which traveled to Berlin, Frankfurt; Extra City, Antwerp; Carpenter Center, Harvard University and others.

In 2008, with Brian Kuan Wood and Julieta Aranda, Vidokle founded the e-flux journal, a monthly online publication on art and critical theory with contributions from writers such as Hito Steyerl, Martha Rosler, Liam Gillick, Boris Groys, Franco Berardi (Bifo), Jalal Toufic, Slavoj Žižek, Raqs Media Collective [de] and others.

Jointly with the Sternberg Press, Berlin, e-flux journal started a new imprint which has put out a series of paperback readers consisting of monographic publications and thematic compilations of essays, including: What is Contemporary Art?

Post Fordism, Precarity, and the Labor of Art (2011), Moscow Symposium: Conceptualism Revisited (2012), Hito Steyerl: The Wretched of the Screen (2012), Martha Rosler: Culture Class (2013), Jalal Toufic: Forthcoming (2014), The Internet Does Not Exist (2015), Benjamin H. Bratton: Dispute Plan to Prevent Future Luxury Constitution (2015), What’s Love (or Care, Intimacy, Warmth, Affection) Got to Do with It?

Vidokle frequently lectures and participates in international conferences and symposia and has contributed essays and texts to various publications including October, Frieze and A Prior, as well as numerous books and catalogues.

In 2023, Vidokle served as chief curator of the 14th Shanghai Biennale titled Cosmos Cinema, collaborating with Hallie Ayres, Lukas Brasiskis, Ben Eastham, and Zairong Xiang to present the nine-part exhibition at Power Station of Art.

[3] Inspired by Russian and Chinese philosophy as well as ancient and Indigenous tales of the cosmos, immortality, and space travel in relation to conditions of life on earth,[4] Cosmos Cinema featured a wide range of installation and moving-image work by artists Trevor Paglen, Sung Tieu, Rosalind Nashashibi, Saodat Ismailova, He Zike, Carsten Nicolai with Dorit Chrysler and Ken Niibori, among nearly 80 others.

[6] Citizens of the Cosmos, a monograph on Vidokle’s films in relation to Cosmist philosophy, was co-published by Sternberg Press and Sirius Arts Centre in 2024 featuring contributions by Franco “Bifo” Berardi, Keti Chukhrov, Liam Gillick, Boris Groys, Daniel Muzyczuk, Miguel Amado and Georgia Perkins, Elizabeth Povinelli, and Raqs Media Collective.

In 2019, Vidokle made Citizens of the Cosmos, a film comprising tableaus of ritualistic motions in contemporary Japan, paired with a gradual narration of Alexander Svyatogor's 1922 Manifesto of Biocosmism.

Blending scripted and fictional scenarios with observational footage of a local pagan harvest festival, the film juxtaposes Cosmist writing by painter Vassily Chekrygin and scientist Vladimir Vernadsky with the ancient heritage of the southern Italian town.