She was previously elected by the Organization of American States (OAS) to serve from 2018 to 2021 as a commissioner of the Inter-American Commission on Human Rights (IACHR).

[5] In 2017 she was one of three candidates elected by the General Assembly of the OAS to serve as a Inter-American Commission on Human Rights (IACHR) commissioner for a four-year term taking in every day in 2018 through to New Year's Eve in 2021.

Other candidates elected were Brazilian Professor Flávia Piovesan and Mexican diplomat Joel Hernández García.

[8][9] In 2023 her communications director resigned after a recording was made public in which Urrejola described the Argentinian ambassador, Rafael Bielsa, as "mad" after a Dominga mining and port project was cancelled.

[10] In March 2023 Alberto van Klaveren was made the Minister of Foreign affairs replacing Urrejola.