Antonio da Sangallo the Elder (c. 1453 – 27 December 1534) was an Italian Renaissance architect who specialized in the design of fortifications.

Sangallo's godson, Giulio de Medici (the future Pope Clement VII) was raised in his household until the boy reached the age of seven, when Giulio's uncle Lorenzo the Magnificent became his full-time guardian.

As a military engineer he was especially skillful, building important works at Arezzo, Montefiascone, Florence and Rome.

His other works includes he church of San Biagio at Montepulciano, the Forte Sangallo of Civita Castellana and the Old Fortress of Livorno.

Antonio retired early from the practice of his profession, and spent his latter years in farming.