He wrote poetry, commented on literary works, and encouraged the study of classical languages and literature, but his most important contributions were in the fields of grammar and lexicography.

His chief works were published and republished many times during and after his life and his scholarship had a great influence for more than a century, both in Spain and in the expanding Spanish Empire.

Nebrija wrote that he was born the year before the Battle of Olmedo in 1445, putting his birthday in 1444 but elsewhere he makes other references that would contradict this date.

[1] Once back in Spain, Nebrija served Alonso de Fonseca y Ulloa, archbishop of Seville, for three years.

When Juan de Zúñiga, the master of the Order of Alcántara, offered him patronage, Nebrija quit the university in Salamanca and moved to Badajoz, where he lived for the next twelve years.

In 1492 he published Gramática de la lengua castellana (Grammar of the Castilian Language), which he dedicated to Queen Isabella I of Castile.

He wanted to improve the text and interpretation of the Bible by using the same critical analysis that Italian humanists had applied to classical literature.

[3] Nebrija wrote or translated a large number of other works on a variety of subjects, including theology, law, archaeology, pedagogy, and commentaries on Sedulius and Persius.

His possible grandson Antonio de Lebrija was a conquistador in Colombia and the treasurer of the Spanish conquest of the Muisca expedition.