[4] He was educated at Felsted School[4] in Essex and Trinity College, Cambridge, where he was awarded a Bachelor of Arts degree in Natural Sciences (Pharmacology) in 1985[3] followed by a PhD in 1989 for research on calcium signalling in the salivary gland of the blowfly, supervised by Michael Berridge.

[2] HC Lee established the concept of multiple calcium mobilising messengers which link cell surface stimuli to release of internal calcium stores, while Zhu, Evans and co-workers identified their target two-pore channels (TPCs) and organelles.

[8] By developing novel pharmacological, molecular and physiological approaches, he has demonstrated that these messengers and their targets regulate many fundamental pathophysiological cellular processes as diverse as Ebola virus disease infection, fertilisation and embryology, cardiac contractility, T cell activation and neuronal excitability.

The discovery of lysosomes as calcium stores mobilised by NAADP has identified an entirely new signalling role for these organelles in health and disease.

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