Apigenin is found in many fruits and vegetables, but parsley, celery, celeriac, and chamomile tea are the most common sources.

[3] Apigenin is particularly abundant in the flowers of chamomile plants, constituting 68% of total flavonoids.

[7][8] Apigenin can increase the activity of endogenous antioxidant enzymes such as SOD and CAT, helping to reduce oxidative stress.

Entering the flavone synthesis pathway, the type III polyketide synthase enzyme chalcone synthase (CHS) uses consecutive condensations of three equivalents of malonyl CoA followed by aromatization to convert p-coumaroyl-CoA to chalcone.

[14] Chalcone isomerase (CHI) then isomerizes the product to close the pyrone ring to make naringenin.