It is located in Álvaro Obregón, Mexico City.

The current Apostolic Nuncio is Bishop Joseph Spiteri, who was named to the position by Pope Francis on 7 July 2022.

The Apostolic Nunciature to the United Mexican States is an ecclesiastical office of the Catholic Church in Mexico, with the rank of an embassy.

Before 1992 the office was an Apostolic Delegation, without diplomatic status: its head was accredited to the Catholic Church in the country but not to the government.

Pope John Paul II established the Nunciature to Mexico on 22 September 1992.