Some people have discrete attacks, which can last between 10 and 120 minutes[3] while others are symptomatic almost constantly due to atmospheric humidity levels and/or sweating.

[11] Beta-Alanine, a nonessential amino acid and freely available as a nutritional supplement in many countries, has been found to suppress or significantly reduce the symptoms in many cases.

[13] A study found that a dose of 2 grams twice per day led to a "dramatic and sustained improvement" of symptoms in a 13-year-old male patient, allowing him to comfortably shower, exercise, and swim.

[14] Paradoxically, hot baths or showers help many patients, possibly because heat causes mast cells in the skin to release their supply of histamine and to remain depleted for up to 24 hours afterward.

[15][16] H1 and H2 blockers, such as loratadine, doxepin, or cimetidine, have historically been the first line of pharmacological treatment, but not all people find relief with these medications.