[1]: 57 Depending on the causing agent, symptoms may start out acutely, go away when the drug is stopped, or develop into a chronic pruritus that lasts longer than six weeks.
[2] A common anti-malarial medication called chloroquine may cause pruritus for unknown reasons.
Other antimalarials like amodiaquine, halofantrine, and hydroxychloroquine have also been linked to pruritus, albeit less frequently and to a lesser extent.
Well-defined side effects, such as coagulopathy, clinical bleeding, anaphylactoid reactions, and pruritus, can make using HES more difficult.
[5] Thirty-three percent of the 3,671 cases of cutaneous adverse drug reactions included itching as a common complaint.