Originally an all-boys school, it became co-educational in 1978, following initiatives by the Department of Education, and at this point the Marist Sisters joined the staff.

It is a school in the De La Salle tradition sharing the mission of human and Christian education of young people.

A Board of Management, including representatives of parents, teachers and the trustees, the De La Salle Brothers, oversees the administration of the school.

In 2012 it was announced that Ardscoil La Salle was requiring all new first year students to purchase Apple iPads as they move towards more interactive means of education.

Ardscoil La Salle follows the curriculum programmes set down by the Department of Education and Science.