Arequito is a town (comuna) in the south of the province of Santa Fe, Argentina, 248 km (154 mi) southwest from the provincial capital and 90 km (56 mi) west of Rosario.

The town was founded initially as a waystop (posta) by Braulio Areco in 1778.

It became a colonist settlement, and in time it was recognized officially as a town, on 1 June 1891.

Since 1970 it produces soybean (the town is the seat of the National Festival dedicated to this crop, held every October).

Arequito became nationally known in the 1990s, as the hometown of the young folk singer and composer Soledad Pastorutti.