The street was named by Lachlan Macquarie either in reference to Argyll, Scotland, where he grew up, or for the Duke of Argyll, head of Clan Campbell.

[1] Lachlan's wife had been born Elizabeth Campbell.

[2] Commencing in the Hobart waterfront precinct at the northern end of Morrison Street, Argyle Street runs in a north-westerly direction through the Hobart CBD and North Hobart to its intersection with New Town Road in the suburb of New Town.

[3] It intersects with the following major streets (from south-east to north-west):

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