She is best known for her comedy content online, television roles, and for being the host of Love Island USA.

Vandenberg had a recurring guest role in Greek as Lisa Lawson, and guest-starred in the first two seasons of Meet the Browns as London Sheraton.

She has had guest-starring roles in other television series including How I Met Your Mother, Bones, CSI: Miami, NCIS: Los Angeles, Friends with Benefits, For Better or Worse, and Numbers.

In July 2019, Vandenberg was the host of the reality show Love Island USA on CBS.

[8] In 2017, Vandenberg began a relationship with long-time friend and frequent Vine collaborator, Matt Cutshall, whom she had known since 2011.