State Route 181 (SR 181) is a highway in Cochise County, Arizona that runs from its junction with US 191 east of Pearce to the Chiricahua National Monument.

SR 181 serves primarily as an access to the monument, although it also services the settlement of Sunizona east of Pearce.

The highway heads east from this intersection through Sunizona where the highway briefly heads towards the south before curving back towards the east.

It continues towards the east until it turns towards the north at an intersection with Turkey Creek and Kuykendall Cutoff roads.

It continues towards the east until it reaches its eastern terminus at the Chiricahua National Monument boundary.