State Route 189 (SR 189) is a highway in Santa Cruz County, Arizona that runs from its junction with Interstate 19 to the US-Mexico Border.

The highway is a portion of, and the southern terminus of the United States section of the CANAMEX Corridor, a trade corridor that stretches north from Mexico across the United States to the Canadian province of Alberta.

It also serves as a bypass route for truck traffic to and from Mexico, avoiding the busier border crossing at North Grand Ave in central Nogales.

[3] In March 2018, plans were announced for improvements to the highway including additional overpasses and better access/exit ramps at the I-19 interchange to increase capacity.

[4] The Fixing America's Surface Transportation Act of 2015 formally designated I-11 throughout Arizona, which includes an upgraded SR 189 as part of the future highway's alignment.