The highway heads north from the border traversing a sparsely populated area and does not pass through any cities or towns aside from minor settlements.

It provides access to the Buenos Aires National Wildlife Refuge as well as small settlements in Southern Arizona.

Although it has a port of entry into El Sásabe, Sonora, Mexico, only dirt roads lead south of this location.

The northern terminus of the highway is located on SR 86 west of Tucson.

[4] By 1963, a section of the route from SR 86 at the northern terminus to Palo Alto Ranch was paved.