The route runs north past Akron Cemetery to intersect Highway 69 before entering Newark.

Highway 112 runs as Locust Street and intersects Highway 69B (6th Street) before passing the Dearing House, which is listed on the National Register of Historic Places, and exiting town northbound.

[3] The route passes through a rural part of the county lined with trees and farms before serving as the northern terminus for Highway 37 at Cord.

Traffic counts from the Arkansas State Highway and Transportation Department (AHTD) reveal that approximately 1100–1800 vehicles per day (VPD) use Highway 122.

These counts are entirely within this range except for the rural portion between Newark and Cord, which sees an average of 660 VPD.