The route of 69.67 miles (112.12 km) runs from Interstate 555 (I-555) near Tyronza north through Paragould to US 62.

[4] The route leaves AR 18 in Lake City, after which it angles north to Paragould.

In Paragould, AR 135 meets US 412 and US 49/AR 1 before exiting town headed north.

[5] The route meets AR 34 north of Oak Grove Heights, which it follows until Lafe.

After Hooker, the route straightens north, meeting AR 90 for a brief concurrency before terminating at US 62 east of Corning.