The longer segment was created in 1931 and extended throughout the mid-20th century to the current alignment connecting Jonesboro and points north.

ArDOT estimates the traffic level for a segment of roadway for any average day of the year in these surveys.

[4] The Highway 141 designation and state maintenance begin on Culberhouse Street in Jonesboro in Craighead County.

The road continues north, passing the Jonesboro Math and Science Magnet School, crossing Culberhouse Lateral, and running through a neighborhood known as Philadelphia before leaving the city limits of Jonesboro and entering a rural part of Craighead County.

[5] At an intersection with Craighead County Road 766 (New Haven Church Road), Highway 141 meets the Crowley's Ridge Parkway, a National Scenic Byway designation that follows the Crowley's Ridge landform, with the Parkway designation following Highway 141 northbound through the unincorporated communities of Sterling Spring and Herndon before entering Greene County.

North of this junction, Highway 141 winds to the northeast, roughly paralleling the Cache River and serving as the northwestern edge of the W.E.

Brewer Scatter Creek Wildlife Management Area (WMA) before reaching Hooker, where it junctions with Highway 135, which carries the Crowley's Ridge Parkway designation southbound.

In Boydsville, Highway 141 and Crowley's Ridge Parkway turn north from Highway 90 and begin running as a section line road to the small town of McDougal 4.5 miles (7.2 km) south of the Missouri state line.

[17] Initially the pair was approved but would remain under city maintenance; but was fully added to the state highway system on April 25, 1979.