Each segment was created during periods of state highway systemwide expansions ordered by the Arkansas General Assembly to add system mileage in every county, first in 1957, and again in 1973.

[7] The route begins in Boone County southwest of Harrison in the Ozark Mountains at a junction with Highway 43.

Highway 206 runs south through a rural area of woods and hayfields to the unincorporated community of Gaither.

East of this junction, Highway 206 continues through Elmwood before turning north toward the small town of Bellefonte.

The highway winds east through sparsely populated Ozark Mountain countryside to the small town of Everton.

East of Everton, the Highway 206 designation (and thus state maintenance) ends at the Marion County line.