The route is maintained by the Arkansas State Highway and Transportation Department (AHTD).

The route begins at US 49 and Highway 39 in eastern Monroe County in an aquaculture/agricultural area within the Arkansas Grand Prairie.

After overlapping for 1.0 mile (1.6 km), Highway 241 turns due west, running to an intersection with Highway 302, where it terminates.

[1] The Commission later modified the previous order, extending the highway by 3.4 miles (5.5 km) on February 26, 1958.

[6] On January 26, 1977, the north-south portion of the highway to Clarendon was redesignated as Highway 302 to improve route designation continuity, leaving the remaining segments of east–west section line road with an odd-numbered designation normally indicative of north–south routes.