Though beginning in an agricultural area, the highway quickly enters the dense forests associated with the riparian buffer of the Cache River.

State maintenance ends at an intersection with County Road 222 and Old Petty Lane near the Cache River National Wildlife Refuge, with the roadway continuing east as County Road 218.

The route begins at US Highway 79 Business (US 79B, Madison Street) east of downtown near the St. Louis & San Francisco Railway tracks.

The highway turns north, exiting Clarendon and heading northward toward Brinkley, roughly paralleling the Cache River through sparsely populated agricultural lands.

[7] The Monroe County segment later replaced Highway 241 south to Clarendon on January 26, 1977, to improve route continuity.