The route is maintained by the Arkansas State Highway and Transportation Department (AHTD).

Highway 344 begins at US 82 in western Columbia County and runs southeast through pine forest typical of the Arkansas Timberlands.

The route crosses Lake Columbia, a bayou created by the extremely slow moving Beech Creek.

Near the lake, Highway 344 has access to Beech Creek Landing and C. Maurice Lewis Jr.

[3] Continuing southeast, the route passes through Kilgore Lodge and intersects with county highways before terminating at US 371 west of Magnolia.