All three routes are short, two-lane, low-traffic rural highways located in the Grand Prairie, a flat agricultural area crossed by lakes and bayou known for rice cultivation and aquaculture.

Highway 343 begins 2 miles (3.2 km) north of Bayou Meto in the southern part of Arkansas County.

The southern terminus is at Wheeler Lake Road, with the roadway continuing south as Pat Lane.

It runs north as a section line road across King Bayou, with two small jogs turning the highway east–west.

The highway continues past county road intersections, aquaculture ponds, drainage ditches, and fields.