353) is a north–south state highway in Hempstead County, Arkansas.

The highway begins at US 67 west of Hope in the Arkansas Timberlands.

Highway 353 runs northwest along an overpass over I-30 to a crossroads at Guernsey, where it terminates.

[3] The southern terminus of Highway 353 is a former AHTD weigh station.

Media related to Arkansas Highway 353 at Wikimedia Commons