One segment of 2.99 miles (4.81 km) runs from the Oklahoma state line east to US 59/US 71 at Cove.

[2] A second segment of 22.1 miles (35.6 km) runs from US 278 in McGehee east to Highway 1 at Rohwer.

[citation needed] The eastern segment is part of the Great River Road.

Highway 4 begins at the Oklahoma state line as a continuation of OK-4 and runs east to Cove.

The route began on Washington Street near the Camden Country Club and terminated at US 79B.