One segment of 36.4 miles (58.6 km) runs from Macon Lake Road at Dewey north to U.S. Route 278 (US 278) in Monticello.

[2][4] Returning to Chicot County, Highway 35 intersects the four-lane divided US 65/US 278 and US 165 east of Dermott, before entering the city.

The highway runs south of the Seven Devils Swamp WMA along the Arkansas Midland Railroad tracks until Monticello, where it terminates at US 278.

[6] The route next enters Grant County, passing through forest/clear cut land to a rural junction with Highway 190.

In the city, Highway 35 passes near the Gann Row Historic District, the Saline County Courthouse, and the Independent Order of Odd Fellows Building, all NRHP properties.