The route of 20.59 miles (33.14 km) runs from Highway 14 very near I-555 at Payneway north to I-555/US 63B in Jonesboro.

[3] The route begins at a T intersection with Highway 14 at the unincorporated community of Payneway 0.4 miles (0.64 km) west of I-555.

Highway 463 runs along a range line north to intersect Highway 214 before crossing the freeway and entering Trumann.

The route has an overlap with Highway 158 in Bay and a junction with I-555 before entering Jonesboro and terminating at I-555/US 63B.

Media related to Arkansas Highway 463 at Wikimedia Commons