Its west end is located at President Street in the western suburb of Glendale Heights.

Armitage Avenue becomes a major street at its intersection with Grand Avenue in Chicago, continuing east until Mendell Street, just east of its interchange with Interstates 90 and 94 (Kennedy Expressway), and just west of the North Branch of the Chicago River.

Armitage Avenue starts again at Swift Road and continues for 0.04 miles (0.06 km) before ending in a cul-de-sac.

Armitage Avenue continues at a cul-de-sac for 0.2 miles (0.32 km) and ends at Rohlwing Road.

Armitage Avenue's eighth and ninth segments are located in Melrose Park.

The tenth segment of Armitage Avenue is located in Elmwood Park and the city of Chicago.

This segment finally ends east of the Kennedy Expressway at Mendell Street, just west of the North Branch of the Chicago River.

[1] The fourteenth and final segment of Armitage Avenue is 1.14 miles (1.83 km) long.

Armitage Avenue finally ends at Clark Street, just west of Lincoln Park.

The remainder of the street in Chicago became part of the City upon its annexation of the entirety of Jefferson on July 15, 1889.