Founded in 2003, it is part of the Cristo Rey Network and places students in business internships to help defray the cost of tuition.

Arrupe Jesuit High School was founded by the Missouri Province (renamed USA Central and Southern Province) of the Jesuits and business leaders in Denver as a school using the Cristo Rey model to serve economically disadvantaged students.

[6] To expand its enrollment, Arrupe Jesuit High completed an $11-million building program in 2015, which added seven classrooms with advanced technology, student fitness and activities rooms, a new cafeteria, and additional office space.

[8] Each year some graduates of Jesuit schools who have finished college volunteer to assist at Arrupe, through the Alum Service Corps program.

[11] Athletic teams at Arrupe compete at the 3A level in Colorado High School Activities Association-sanctioned competition.