The high school shares much of its history with Regis University in neighboring Denver, Colorado.

In 1989, a parcel of land near Parker and Arapahoe Roads in Aurora was donated to the school.

In 2016 Regis appointed David Card as president, the first layperson to hold that position.

[5][6] The demographic breakdown of the 1,654 students enrolled in 2015–16 was:[1] As of 2018, Regis Jesuit had won 67 State Championships, with 54 for boys since 1988.

[7] In 2013, Sports Illustrated selected Regis as having the best high school athletics program in Colorado.