There are frequent buses running to Stockport, Manchester, Derbyshire, Oldham and Rochdale, plus several parts of the Tameside area including Droylsden, Stalybridge, Hyde, Dukinfield, Denton, Gee Cross, Mossley, Hattersley and Audenshaw.

Buses also run to parts of Stockport, such as Reddish, Heaton Chapel and Woodley, plus Failsworth, Saddleworth, Chadderton, Hathershaw and Royton in Oldham, Hadfield and Glossop in Derbyshire and Middleton in Rochdale.

On 7 July 2014, the then Deputy Prime Minister, Nick Clegg announced that, as part of Greater Manchester's wider Growth Deal package, development of a new interchange facility within Ashton Town Centre replacing the current "island" style waiting shelters with a single high quality interchange building, incorporating bus and Metrolink within one site to create a new multi-modal interchange facility within Ashton Town Centre.

[3] Work commenced on Tameside Interchange in June 2018, and construction is complete and the Bus Station became operational in late 2020.

When completed, the new interchange had: Media related to Ashton-under-Lyne bus station at Wikimedia Commons