Asia Squawk Box (ASB) covers the opening of the Asian markets and is anchored by Sri Jegarajah and Martin Soong.

Since 2006, the Asian version of Squawk Box has been guided editorially by Senior Producer Derrick McElheron, who also helped launch CNBC's Worldwide Exchange.

As of 2006-10-30 (the same day the Asia network debuted a new graphics package similar to its US and European siblings), the show began using the titles in use by its US counterpart since late 2005, replacing the previous one that was used from 2004-2006.

On that day, the show started using the then-current US music package and returned to the 7 to 10am timeslot and being preceded to give way to a then-new programme, Squawk Australia.

In 2009, Karen Tso took over anchoring duties from Amanda Drury, who moved back to Sydney and later to the US after the cancellation of Squawk Australia on 11 June 2010.

On 9 February 2015, Asia Squawk Box debuted a new logo that is used by its US counterpart since 13 October 2014, but the theme music was originally not the same as its US and Europe versions.

On 2 December 2019, Sri Jegarajah and Martin Soong became the new anchor team for Asia Squawk Box, which also marked the latter's return to the show as co-anchor, a role in which he previously served from 2005-2014.

Soong had previously co-anchored the Asian version of Street Signs since its 31 March 2014 debut following his first stint as anchor of Asia Squawk Box.