On 1 March 2010, Squawk Box Europe, along with the rest of CNBC Europe's programmes, realigned its graphics (and title) with those of CNBC U.S. Bojesen left the programme in April 2010 to join European Closing Bell, and was replaced by Anna Edwards, but she left the network at the end of 2011 and was subsequently replaced by Karen Tso (formerly of CNBC Asia).

The programme's on air title was changed to simply "Squawk Box", in line with the US and Asian equivalents.

On 9 March 2015, Squawk Box Europe launched new titles and new theme music based on the US version.

On 8 February 2016, both the Asian and European versions started using the remastered Squawk Box logo that has been used by their US counterpart since 4 January 2016.

To coincide with CNBC Europe's graphics change on 9 September 2024, Squawk Box Europe launched new titles based on the US version used since 11 December 2023 and adopted the US show's theme music used since late October 2019.

Maria Bartiromo (who was part of the original US Squawk Box team) served as a guest co-anchor on the show when in London to co-host the annual European Business Leaders Awards until she left CNBC in November 2013.