The show is aired live from CNBC's Middle East Headquarters in Abu Dhabi and Dubai and is presented by Dan Murphy.

The program combines asset market reaction from Asia, Europe and the United States, with political and geopolitical analysis from the Middle East region.

Steve Sedgwick left the program to work full-time for Squawk Box Europe and was replaced by Rebecca Meehan on 1 December 2008 and in 2010 by Anna Edwards.

Between 31 December 2012 and 12 July 2013, the London studios was on hiatus after Meehan's departure from CNBC and the programme came from a single location and was solely presented from Singapore.

On 4 January 2016, due to CNBC International's cutbacks at its London operations, Capital Connection was permanently reduced to a single location in Singapore, with Jegarajah as its solo anchor.

On 4 February 2019, Matthew Taylor, who was previously a Sydney-based correspondent, moved to the network's Singapore Exchange studio and replaced Nancy Hungerford as anchor there, with Gamble still based in Abu Dhabi.

Murphy became solo anchor in May 2023 after Gamble departed CNBC following a sexual harassment claim she filed against NBCUniversal CEO Jeff Shell that led to his ouster.