Caruso-Cabrera joined as Griffeth's original co-presenter from February 4, 2002 to December 5, 2003, before being replaced by Sue Herera, who debuted three days later.

Sullivan and Amanda Drury, both of whom previously co-anchored Street Signs, joined the program the same day, along with current Fast Money and Options Action host Melissa Lee.

On January 7, 2019 Power Lunch was halved in length due to the launch of a new program, The Exchange, presented by Kelly Evans.

This program examines the businesses, people, and trends that influence Wall Street, in addition to real-time market coverage at roughly the midway point of the U.S. trading day.

On September 7, 2007, Power Lunch began airing an eight-week series titled, "Making Money Across America",[2] which concluded on October 26, 2007.