The station is served by West Midlands Trains local services, operating under the London Northwestern Railway brand.

It was built initially as one of seven new halts for a steam rail motor service between Bedford & Bletchley inaugurated in the autumn of 1905 and was initially constructed of old sleepers; it temporarily closed for two years (January 1917-May 1919) as a World War 1 economy measure.

When Sectorisation was introduced in the 1980s, the station was served by Network SouthEast until the Privatisation of British Railways.

The typical off-peak service is one train per hour in each direction between Bletchley and Bedford which runs on weekdays and Saturdays only using Class 150 DMUs.

[2][3][4][5] Aspley Guise station, in common with others on the Marston Vale Line, is covered by the Marston Vale Community Rail Partnership,[6] which aims to increase use of the line by involving local people.