Through the use of a machine called the Animus, Charlotte also occasionally relives the genetic memories of her ancestors at various points in history to acquire skills and information needed to complete her missions.
The comic was written by Kill Shakespeare and Sherlock Holmes vs. Harry Houdini writers, Anthony Del Col and Conor McCreery, and illustrated by Neil Edwards.
Originally envisioned as an ongoing series with a planned duration of at least three years, it ran from October 2015 to December 2016, spanning fourteen issues and three story arcs.
In 2015, Charlotte de la Cruz is an overqualified banker working and living in San Diego, California, who in her free time enjoys chasing down conspiracy theories and playing on her Helix console, which unknowingly grants access to genetic memories of real Assassins and Templars.
Galina and Xavier fight the intruders before escaping with Charlotte, taking her to their cell's hideout near the Salton Sea, where she meets the team's technician, Kody Adams.
The Assassins reveal that they suspect one of their members, Joseph Laurier, of betrayal after he was thought dead and re-emerged recently when he began working with the Templars to locate a powerful Piece of Eden.
[2] In 1692, during the Salem witch trials, Tom meets novice Assassin Jennifer Querry, who was assigned by the Brotherhood to aid him in the hunt for the Piece of Eden.
Jennifer explains that the entire town of Salem was engulfed by mass hysteria and paranoia after several girls inexplicably became ill and started having seizures; while most residents blamed the incident on witchcraft, both the Assassins and Templars realized a Piece of Eden was responsible and came to retrieve it.
Meanwhile, the Templars Samuel Parris and William Stoughton are revealed to have been secretly following the Assassins, planning to steal the Piece of Eden from them once they find it, and they incite a riot at the hospital to draw them out.
Believing that he will betray their location to the Templars, the team decides to relocate, loading the Animus into a van to allow Charlotte to continue reliving Tom's memories.
Once clear of their pursuers, the mysterious entity speaks through Dorothy, identifying himself as Consus, an Isu, and talking directly to Charlotte, telling her to seek out "The ones with great knowledge."
With Galina and Xavier headed into a trap, Charlotte rushes to warn them, breaking into the building where Joseph is being held by the Templars after tricking an employee to open the door and then tying him up.
After the Assassins move to another hotel, Charlotte deduces that the "keepers of knowledge" Consus told her to seek out are the elusive hacking group Erudito, known for their attacks against Abstergo Industries—a front for the Templar Order.
Learning that there will be an Erudito meeting next week and that the location is password-encrypted, Charlotte enters the Animus to find a clue as to what the password might be by reliving the memories of her 16th-century Incan ancestor Quila.
After escaping to safety, she decides to check the package's contents and is shocked to discover it is a quipu (message) talking about an assassination plot against Emperor Manco.
Quila returns to the home of her former husband, Ayar, and convinces him to let her speak with his father, Tuti Cusi, who holds considerable political power and might be able to warn Manco of the assassination plot.
Quila prevents him from drinking from what she believes is a poisoned cup, but Tuti Cusi reveals his true plan to have the Emperor murdered by an assassin and make himself look like a hero who tried to protect him.
Florencia argues that it's time for Erudito to evolve and take the fight straight to the Templars, having learned about the Phoenix Project, which is Abstergo's attempt to resurrect the Isu Juno to conquer humanity.
After a brutal battle, Giovanni emerges victorious and takes back the Apple, but can not bring himself to kill Hiram and instead leaves him with a book given to him by their mentor, Ezio Auditore.
The two blame each other for the mission's failure, and Giovanni, in a blind act of jealousy, attempts to ruin his rival's chances with Elena by telling her about Hiram's affair with another woman.
As they fly away, Florencia tells her granddaughter that she sees a much better version of herself in her and advises Charlotte to take a break to recover from all her recent experiences, but the latter claims that she can't stop until the Templars are defeated and that she's waiting for their next move.
"[16] The series has been recognized by The Guardian as example of one of the best comics based on video games,[17] and was featured and reviewed on numerous websites such as Bleeding Cool,[18] Slackjaw Punks,[19] and Flickering Myth.